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Effects of Varying Doses in Man

Solomon H. Snyder, MD; Herbert Weingartner, PhD; Louis A. Faillace, MD

Arch Gen Psychiatry. 1971;24(1):50-55.

Abstract
DOET (2,5-dimethoxy-4-ethylamphetamine) is a new psychotropic agent which chemically resembles mescaline and amphetamine. It is essentially the ethyl homologue of DOM (2,5-dimethoxy-4-methylamphetamine), a psychotomimetic drug widely used by hippie populations and designated "STP." DOET was administered to normal male subjects in doses ranging from 0.75 to 4 mg and contrasted with effects of a water placebo. In all cases DOET produced subjective effects including a mild euphoria, a feeling of enhanced self-awareness, and a tendency to feel "anxious" at higher doses. Although there was some increase in subjective effects at higher doses, this was not marked. No hallucinogenic or psychotomimetic effects were observed at any dose. Thus, over a five-fold range of pharmacologically active dosage, the "enhanced awareness" produced by DOET was not associated with psychotomimetic or hallucinogenic actions.

PSYCHEDELIC drugs embrace a large number of agents of widely different chemical classes but which produce notably similar profound subjective effects.¹ Nuances of subjective effects which may vary among drugs² have not been well quantified.

Shulgin^3.4 has synthesized a large number of methoxylated amphetamines related to mescaline and amphetamine. One of these, DOM (2, 5-dimethoxy-4-methylamphetamine) (Fig 1), informally designated "STP," was psychotomimetic and hallucinogenic in doses larger than 5 mg, and was about 50 to 100

Author Affiliations
Baltimore

From the departments of pharmacology and experimental therapeutics (Dr. Snyder) and psychiatry and the behavioral sciences (Drs. Snyder, Weingartner, and Faillace), Johns Hopkins University School of Medicine, Baltimore.

Footnotes
Accenpted for publication March 16, 1970.

Reprint requests to Department of Pharmacology, Johns Hopkins University School of Medicine, 725 N Wolfe St, Baltimore 21205 (Dr. Snyder).

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Stereospecific Actions of DOET (2,5-Dimethoxy-4-Ethylamphetamine) in Man
Snyder et al.
Arch Gen Psychiatry 1974;31:103-106.
ABSTRACT