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Richard J. Wyatt, MD; Barry Portnoy, MD; David J. Kupfer, MD; Frederick Snyder, MD; Karl Engelman, MD

Arch Gen Psychiatry. 1971;24(1):65-70.

Abstract
The total resting plasma catecholamine concentration from 13 drugfree, depressed patients was found to be significantly elevated over concentrations from 47 normal controls. Differential determinations of epinephrine and norepinephrine revealed that both catecholamine components were elevated in the Patients. The literature on norepinephrine concentrations in brain, spinal fluid, and urinary excretion was reviewed and indicated that rather than being decreased, norepinephrine has been found to be either unchanged or increased in depressed patients.

Author Affiliations
Bethesda, Mdn

From the Laboratory of Clinical Psychobiology, National Institute of Mental Health and Branch on Experimental Therapeutics, National Institutes of Health, Bethesda, Md. Dr. Wyatt is now with the Laboratory of Clinical Psychopharmacology, Special Mental Health Research Division, National Institute of Mental Health, St. Elizabeth's Hospital, Washington DC, and Drs. Portnoy and Kupfer are now with Yale New Haven (Conn) Hospial.

Footnotes
Accepted for publication March 10, 1970.

Reprint requests to Laboratory of Clinical Psychobiology, National Institute of Mental Health, Bldg 10, Room 3N222, Bethesda, Md 20014 (Dr. Wyatt).

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