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A Genetic Study

George Winokur, MD; Remi Cadoret, MD; Joe Dorzab, MD; Max Baker, MD

Arch Gen Psychiatry. 1971;24(2):135-144.

Abstract
One hundred depressive probands have been examined. A family history was obtained on each of the probands, and a family study was done on 129 primary relatives of these probands. An analysis of the genetic data is in favor of the possibility that at least two types of depressive illness exist. One of these may be called "depression spectrum disease." The prototype of this would be a female with an onset prior to age 40 in whose family more depression is seen in female relatives than male relatives and the deficit in males is made up by alcoholism and sociopathy. The second prototype is that of pure depressive disease in which the proband is a male whose illness starts after age 40 and in whom there are equal amounts of depression in both male and female relatives and no large amount of alcoholism or sociopathy in the males.

Author Affiliations
St. Louis

From the Department of Psychiatry, Washington University School of Medicine, St. Louis.

Footnotes
Accepted for publication Aug 27, 1970.

Reprint requests to Department of Psychiatry, Washington University School of Medicine, 4940 Audubon Ave, St. Louis 63110 (Dr. Winokur).

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