Total Prolonged Drug-Induced REM Sleep Suppression in Anxious-Depressed Patients

doi:10.1001/archpsyc.1971.01750080049007

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Vol. 24 No. 2, February 1971

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Total Prolonged Drug-Induced REM Sleep Suppression in Anxious-Depressed Patients

Richard J. Wyatt, MD; David H. Fram, MD; David J. Kupfer, MD; Frederick Snyder, MD

Arch Gen Psychiatry. 1971;24(2):145-155.

Abstract

Monoamine oxidase inhibitors (MAOI) are a class of drugs whichare capable of totally suppressing REM sleep. The MAOI phenelzinewas given to six anxious-depressed patients while daily behavioraland EEG sleep records were made. REM sleep was completely suppressedfor from 14 to 40 nights. Upon discontinuation of MAOI REM sleepincreased as much as 250% above normal levels. The bipolar EEGchanges were paralleled by similar changes in depression andanxiety. The behavior of all six patients markedly improvedat times when REM sleep was completely absent. Two of the fourpatients studied after MAOI discontinuation became profoundlyanxious with REM compensation. The morning recall of dreamsalso closely paralleled the presence or absence of REM sleep.Evidence from this study and others indicate that suppressionof REM sleep might help to alleviate depression.

Author Affiliations

Bethesda, Md

From the Laboratory of Clinical Psychobiology, DCBR, National Institute of Mental Health, Bethesda, Md. Dr. Wyatt is currently at the Laboratory of Clinical Psychopharmacology, Special Mental Health Research Division, NIMH. Dr. Kupfer is currently at the Yale New Haven Hospital, New Haven, Conn.

Footnotes

Accepted for publication April 1, 1970.

Reprint requests to Laboratory of Clinical Psychobiology, NIMH,Building 10, Room 3N222, Bethesda, Md 20014 (Dr. Wyatt).

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