 |
|
Acetophenazine and Diazepam in Anxious Depressions
Leo E. Hollister, MD;
John E. Overall, PhD;
Alex D. Pokorny, MD;
Jack Shelton, MD
Arch Gen Psychiatry. 1971;24(3):273-278.
Abstract
| |
Sixty-seven newly admitted depressed patients were classified on the basis of their presenting signs and symptoms as having the syndrome of anxious depression. They were assigned randomly either to treatment with the phenothiazine derivative, acetophenazine, or with the antianxiety drug, diazepam. After four weeks of treatment, both groups were equally improved. Study of the interactions between drugs and demographic variables revealed that patients with less long-term and uncomplicated depressions responded better to diazepam, the converse being true for acetophenazine. Although our previous studies indicated that phenothiazine derivatives were preferable to conventional tricyclic antidepressants in patients with anxious depressions, antianxiety agents are also effective. In fact, because most patients fall into the group which responds best to them, as well as because of their greater safety, drugs such as diazepam might be the first choice for treating the most common depressive syndrome, that of anxious depression.
Author Affiliations
Palo Alto, Calif; Galveston, Tex; Houston; Palo Alto, Calif
From the Veterans Administration Hospital, Palo Alto, Calif (Drs. Hollister and Shelton), the University of Texas Medical Branch, Galveston (Dr. Overall), and the Veterans Administration Hospital, Houston (Dr. Pokorny). Dr. Shelton is now at Shasta General Hospital, Redding, Calif.
Footnotes
Accepted for publication July 29, 1970.
Reprint requests to Veterans Administration Hospital, 3801 Miranda Ave, Palo Alto, Calif 94304 (Dr. Hollister).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Alprazolam, Diazepam, Imipramine, and Placebo in Outpatients With Major Depression
Rickels et al.
Arch Gen Psychiatry 1987;44:862-866.
ABSTRACT
Imipramine and Chlordiazepoxide in Depressive and Anxiety Disorders: I. Efficacy in Depressed Outpatients
Lipman et al.
Arch Gen Psychiatry 1986;43:68-77.
ABSTRACT
Alprazolam, Amitriptyline, Doxepin, and Placebo in the Treatment of Depression
Rickels et al.
Arch Gen Psychiatry 1985;42:134-141.
ABSTRACT
Benzodiazepines in Depressive Disorders
Schatzberg and Cole
Arch Gen Psychiatry 1978;35:1359-1365.
ABSTRACT
Depression Subtypes and Response to Phenelzine, Diazepam, and a Placebo: Results of a Nine Hospital Collaborative Study
Raskin et al.
Arch Gen Psychiatry 1974;30:66-75.
ABSTRACT
Drug Treatment of Anxiety and Depression in Detoxified Alcoholic Patients
Overall et al.
Arch Gen Psychiatry 1973;29:218-221.
ABSTRACT
Drug Spotlight Program: Uses of Psychotherapeutic Drugs
HOLLISTER
ANN INTERN MED 1973;79:88-98.
ABSTRACT
|
