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Baron Shopsin, MD; Samuel Gershon, MBBS, DPM

Arch Gen Psychiatry. 1971;24(4):320-326.

Abstract
Adrenocortical overactivity as a theory in the pathogenesis of depression cannot be supported on the basis of this study. Plasma cortisol response to dexamethasone was normal in both bipolar and unipolar depressives, reactive depressives and schizophrenics. As a group, schizophrenics showed significantly higher morning cortisol values than the depressed population.

Author Affiliations
New York

From the Neuropsychopharmacology Research Unit, Department of Psychiatry, New York University Medical Center, New York.

Footnotes
Accepted for publication June 2, 1970.

Reprint requests to Department of Psychiatry, New York University Medical Center, School of Medicine, 550 First Ave, New York 10016 (Dr. Gershon).

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