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Chlorpromazine and Diphenhydramine

Julius Korein, MD; Barbara Fish, MD; Theodore Shapiro, MD; Edward W. Gerner, MD; Luci Levidow

Arch Gen Psychiatry. 1971;24(6):552-563.

Abstract
The results of a double-blind study evaluating the EEG and behavioral effects of chlorpromazine hydrochloride and dyphenhydramine hydrochloride on 29 children indicate that EEG findings alone can show whether or not a child is receiving medication. There was also a significant correlation between the more marked clinical behavior changes and the more marked EEG changes. The EEG effects of both drugs included slow alpha waves and generalized slowing, in the case of diphenhydramine hydrochloride, high voltage 4 to 6 cycle per second activity was uniformly produced by the relatively high doses used in this study.

Author Affiliations
New York; New Orleans; New York

From the departments of psychiatry and neurology, New York University Medical Center (Drs. Korein, Fish, and Shapiro and Miss Levidow), Bellevue Medical Center (Drs. Korein and Fish), and the Department of Neurology, US Public Health Service Hospital, New Orleans (Dr. Gerner). Dr. Korein is a Health Research Council Career Scientist of the city of New York.

Footnotes
Accepted for publication June 2, 1970.

Reprint requests to New York University Medical Center, 550 First Ave, New York 10016 (Dr. Korein).

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