This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (33)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Part II

Herbert Y. Meltzer, MD; Robert Nankin; John Raftery

Arch Gen Psychiatry. 1971;24(6):568-572.

Abstract
Serum creatine phosphokinase (CPK) activity was determined in 726 patients and correlated with psychiatric diagnosis. Eighty-three of 209 acutely psychotic patients (39.7%) had increased serum CPK activity. The incidence of increased CPK levels in those patients with symptoms of less than two weeks' duration (65.1%) was significantly higher than in those whose symptoms were dated to more than two weeks prior to hospitalization (10.3%). The median increase was four to five times the upper limit of normal. Increases were present in patients with the whole range of acute psychotic syndromes not previously attributed to physical conditions. Few nonpsychotic and chronically psychotic patients had elevated serum CPK levels. Some patients with alcoholic psychoses or cerebral arteriosclerosis had elevated serum CPK activity. The determination of serum CPK activity may be of some use for diagnostic purposes.

Author Affiliations
Chicago

From the Department of Psychiatry, University of Chicago Pritzker School of Medicine (Dr. Meltzer, Mr. Nankin, and Mr. Raftery) and the Illinois State Psychiatric Institute (Dr. Meltzer), Chicago.

Footnotes
Accepted for publication Feb 19, 1971.

Reprint requests to Department of Psychiatry, University of Chicago Pritzker School of Medicine, 950 E 59th St, Chicago 60637 (Dr. Meltzer).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Effects of Isometric Exercise on Serum Creatine Phosphokinase Activity
Goode and Meltzer
Arch Gen Psychiatry 1976;33:1207-1211.
ABSTRACT  

Creatine Phosphokinase Activity and Clinical Symptomatology: A Study in Acute Schizophrenic Patients
Meltzer
Arch Gen Psychiatry 1973;29:589-593.
ABSTRACT  

Nonmetric Pattern Analysis of Behavioral and Biological Disease Symptoms in Alcoholism
Layden and Smith
Arch Gen Psychiatry 1973;28:246-249.
ABSTRACT  

Central Core Fibers in an Acutely Psychotic Patient: Evidence for a Neurogenic Basis for the Muscle Abnormalities in the Acute Psychoses
Meltzer
Arch Gen Psychiatry 1972;27:125-132.
ABSTRACT