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Research With PsychedelicsSome Biopsychological Concepts and Possible Clinical Applications
Julian Silverman, PhD
Arch Gen Psychiatry. 1971;25(6):498-510.
Abstract
Recent studies of the sensory effects of psychedelic drugs indicate druginduced sensitivity to minimal and ordinary stimulation. This kind of laboratory observation accords with subjective reports that psychedelicdrugged subjects' sensory experiences are intensified and that they are aware of qualities of sensory experience which they never were before. Paradoxically, these individuals also evidence an increased tolerance for strong stimulation. The paradox is explained by an experimentally derived model of differential excitation which indicates how psychedelic drugs act differently on parts of the brain. The literature on various aspects of laboratory and clinical research with psychedelic drugs is reviewed on the basis of this formulation.
Author Affiliations
San Jose, Calif
Accepted for publication Feb 22, 1971.; From the Department of Mental Hygiene, Agnews State Hospital, San Jose, Calif, and the Esalen Institute, Big Sur, Calif.
Footnotes
Reprint requests to Department of Mental Hygiene, Agnews State Hospital, San Jose, Calif 95114.
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