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Richard C. Fowler, MD; Michael S. McCabe, MD; Remi J. Cadoret, MD; George Winokur, MD

Arch Gen Psychiatry. 1972;26(2):182-185.

Abstract
Previous family studies of good and poor prognosis schizophrenia are deficient in controlling for investigator bias and none have attempted to interview all available first degree relatives. This study attempted to correct for both of these deficiencies. One hundred fourty-four relatives of 25 poor prognosis and 28 good prognosis schizophrenics were systematically interviewed for psychiatric illness. Results showed a significant preponderance of affective disorder over schizophrenia in the families of patients with good prognosis and the reverse in the families of patients with poor prognosis. This finding is consistent with previous investigations. It confirms that family studies do not validate good prognosis schizophrenia as schizophrenia and suggests that most good prognosis cases are variants of affective disorder.

Author Affiliations
St. Louis

From the Department of Psychiatry, Washington University School of Medicine, St. Louis. Dr. Winokur is currently at the University of Iowa and Dr. McCabe is at the Institute of Psychiatry, Risskov, Denmark on a NIMH special fellowship.

Footnotes
Accepted for publication Sept 21, 1971.

Read before the 124th annual meeting of the American Psychiatric Association, Washington, DC, May, 1971.

Reprint requests to Department of Psychiatry, Washington University School of Medicine, 4940 Audubon Ave, St. Louis 63110 (Dr. Cadoret).

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