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Alec Coppen, MD, DPM; Arthur J. Prange, Jr., MD; Chapel Hill, NC; Peter C. Whybrow, MB, DPM; R. Noguera, MD, DPM

Arch Gen Psychiatry. 1972;26(5):474-478.

Abstract
The end product of serotonin metabolism, 5-hydroxyindoleacetic acid (5-HIAA), is reduced in the cerebrospinal fluid of both manic and depressed patients. The decrement in this substance, however, does not correlate with severity of illness in either condition. The decrement persists after clinical recovery in depressed patients. These findings must be integrated with current concepts about the role of brain biogenic amines in affective disorders.

Author Affiliations
Epsom, England; Hanover, NH; Epsom, England

From the Medical Council Clinical Investigation Unit, Greenbank, West Park Hospital, Epsom, England (Drs. Coppen and Noguera); the Department of Psychiatry, University of North Carolina Medical School, Chapel Hill (Dr. Prange); and the Department of Psychiatry, Dartmouth Medical School, Hanover, NH (Dr. Whybrow).

Footnotes
Accepted for publication Aug 21, 1971.

Reprint requests to Medical Research Council Clinical Investigation Ward, Greenbank, West Park Hospital, Epsom, Surrey, England (Dr. Coppen).

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