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The Effect of Age and Hospitalization on Behavioral Dose-Response Relationships

Mervin L. Clark, MD; H. Rudy Ramsey, PhD; Don K. Rahhal, MD; Eustace A. Serafetinides, MD, PhD; Fredda D. Wood; J. Paul Costiloe, MS

Arch Gen Psychiatry. 1972;27(4):479-483.

Abstract
Behavioral data from a previous study were stratified by age (< 40 or > 40 years) and duration of hospitalization (< 10 or > 10 years) and examined for dose-response relationships at the 12th week of treatment with either placebo or 150, 300, or 600 mg chlorpromazine per day.

It was found that the shorter hospitalized patients (< 10 years) and to a lesser extent, the younger patients (< 40 years) as well, responded better to the higher dose (600 mg/day) whereas the longer hospitalized patients (> 10 years) and older patients ( 40 years) achieved no improvement in response beyond 300 mg/day.

Author Affiliations
Oklahoma City

From the Division of Clinical Pharmacology, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, and Central State Griffin Memorial Hospital, Norman, Okla (Dr. Clark); the Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City (Dr. Serafetinides): and the Division of Clinical Pharmacology, Department of Medicine, University of Oklahoma Health Sciences Center (Drs. Ramsey, Rahhal, Wood, and Costiloe).

Footnotes
Accepted for publication April 6, 1972.

Reprint requests to the University of Oklahoma Health Sciences Center, 800 NE 13th St, Oklahoma City 73104 (Dr. Clark).

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