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Garfield Tourney, MD; Lon Hatfield, PhD

Arch Gen Psychiatry. 1972;27(6):753-755.

Abstract
Peripheral plasma androgen levels have been studied in control subjects, acute, chronic institutionalized, and chronic noninstitutionalized schizophrenic patients. The androgens determined included testosterone, dehydroandrosterone, and androstenedione. The schizophrenic groups did not show any significant difference from controls for plasma levels of testosterone and androstenedione. Both chronic schizophrenic groups have a significantly lower level of dehydroandrosterone. This change appears to be independent of age and institutionalization variables. Dehydroandrosterone is derived principally from the adrenal cortex and this suggests the possibility of reduced adrenal cortical functioning in chronic schizophrenia.

Author Affiliations
Iowa City

From the Department of Psychiatry, University of Iowa College of Medicine, Iowa City (Dr. Hatfield) and the Lafayette Clinic and the Department of Psychiatry, Wayne State University School of Medicine, Detroit (Dr. Tourney).

Footnotes
Accepted for publication June 14, 1972.

Reprint requests to the Department of Psychiatry, Wayne State University, Lafayette Clinic, 951 Lafayette, Detroit 48207 (Dr. Tourney).

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