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Marihuana and Alcohol

Bert S. Kopell, MD; J. R. Tinklenberg, MD; L. E. Hollister, MD

Arch Gen Psychiatry. 1972;27(6):809-811.

Abstract
In a double-blind study, the amplitude of the contingent negative variation (CNV) was assessed in 12 normal men given placebo and quantified "social" doses of 1-⁹-transtetrahydrocannabinol (THC) and alcohol (ethyl alcohol). Using subjects as their own controls, it was found that THC selectively enhanced the amplitude as compared to placebo while alcohol depressed it.

Author Affiliations
Palo Alto, Calif

From the Department of Psychiatry, Stanford University School of Medicine and Palo Alto Veterans Administration Hospital, Palo Alto, Calif.

Footnotes
Accepted for publication May 30, 1972.

Read before a meeting of the Psychiatric Research Society, Boston, Oct 16, 1971.

Reprint requests to the Department of Psychiatry, Stanford University School of Medicine, Stanford, Calif 94305 (Dr. Kopell).

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