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David S. Janowsky, MD; M. Khaled El-Yousef, MD; John M. Davis, MD; H. Joseph Sekerke, PhD

Arch Gen Psychiatry. 1973;28(2):185-191.

Abstract
Methylphenidate (Ritalin) hydrochloride was administered intravenously to schizophrenic, manic, and depressed patients during the active phase of their illness and upon recovery and to normal. Methylphenidate was found to activate psychotic symptoms in schizophrenics during the active phase of their illness. It failed to produce this effect in the same patients after remission had occurred. It failed to produce a psychotic reaction in most patients with mania and all normal or depressed patients.

Author Affiliations
Nashville, Tenn

From the departments of psychiatry and pharmacology, Vanderbilt University School of Medicine and the Tennessee Neuropsychiatric Institute, Nashville, Tenn.

Footnotes
Accepted for publication Oct 11, 1972.

Reprint requests to Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tenn 37203 (Dr. Janowsky).

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