This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

An Assessment of Norepinephrine Metabolism in Affective Disorders

Baron Shopsin, MD; Sherwin Wilk, PhD; Samuel Gershon, MD; Kenneth Davis, PhD; Michael Suhl, MD

Arch Gen Psychiatry. 1973;28(2):230-233.

Abstract
The level of 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) was measured in the cerebrospinal fluid (CSF) of 27 hospitalized psychiatric patients, the great majority of whom show CSF MHPG levels within the range found in 24 normal control subjects. All depressed patients showed normal CSF MHPG levels. Some manic and schizophrenic patients showed levels elevated beyond the range of controls, with greatest significance attained in the manics. Those patients showing abnormal values did not show clinical-chemicaldemographic characteristics distinguishing them from other patients with the same diagnosis.

Using each patient as his own control and relating the time of spinal tap to symptom onset or change may be a sensitive and relevant index of exploring alterations in CSF MHPG.

Author Affiliations
New York

From the Department of Psychiatry, Neuropsychopharmacology Research Unit (Drs. Shopsin and Gershon) and the Department of Neurology (Dr. Suhl), New York University Medical Center, and the Department of Pharmacology, Mount Sinai School of Medicine of the City University of New York (Drs. Wilk and Davis), New York.

Footnotes
Accepted for publication Aug 14, 1972.

Reprint requests to 550 First Ave, New York 10016 (Dr. Shopsin).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Afternoon Continuous Plasma Levels of 3-Methoxy-4-hydroxyphenylglycol and Age: Distinctive Biologic Subgroups of Endogenous Depression?
Halbreich et al.
Arch Gen Psychiatry 1987;44:804-812.
ABSTRACT  

Lithium Carbonate Treatment of Mania: Cerebrospinal Fluid and Urinary Monoamine Metabolites and Treatment Outcome
Swann et al.
Arch Gen Psychiatry 1987;44:345-354.
ABSTRACT  

Clinical and Biochemical Heterogeneity of Depressive Disorders
MAAS
ANN INTERN MED 1978;88:556-563.
ABSTRACT  

The Switch Process in Manic-Depressive Psychosis
BUNNEY et al.
ANN INTERN MED 1977;87:319-335.
ABSTRACT  

Parachlorophenylalanine Reversal of Tranylcypromine Effects in Depressed Patients
Shopsin et al.
Arch Gen Psychiatry 1976;33:811-819.
ABSTRACT  

Biogenic Amines and Depression: Biochemical and Pharmacological Separation of Two Types of Depression
Maas and Maas
Arch Gen Psychiatry 1975;32:1357-1361.
ABSTRACT