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Phenelzine, Mood Response, and Sleep
Desmond L. Dunleavy, MB, ChB;
Ian Oswald, MD
Arch Gen Psychiatry. 1973;28(3):353-361.
Abstract
The monoamine oxidase inhibitor antidepressant, phenelzine, will abolish the signs of REM sleep after a delay of days or weeks. In a study utilizing 22 patients suffering from endogenous depression, the time course of mood change was related to the time course of the induced REM sleep change. A period of placebo administration preceded administration of 60, 75, or 90 mg of phenelzine dihydrogen sulfate daily.
Patient self-ratings of mood were employed and independent judges selected the date of onset of sustained mood improvement with at least three out of four in agreement for nine of the patients. In these nine depressed patients, restoration of normal mood coincided with the delayed abolition of the signs of REM sleep.
Author Affiliations
Edinburg
From the Department of Psychiatry, University of Edinburgh, Scotland. Dr. Dunleavy is currently with the Department of Psychiatry, University of Nottingham, England.
Footnotes
Accepted for publication Nov 15, 1972.
Reprint requests to the Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh EH10 5HF, Scotland (Dr. Oswald).
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