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Prediction of Response to Psilocybin

Yvonne Panton, MD; Roland Fischer, PhD

Arch Gen Psychiatry. 1973;28(3):434-438.

Abstract
Eight "stable" and four "variable" college-age subjects were given 160µg/kg psilocybin under conditions of sensory attenuation. Stability was defined by the magnitude of the standard deviation on handwriting area under predrug conditions.

Only the variable subjects, our large-standard deviants, responded to the drug with a significant decrease in mean pulse rate and increase in handwriting area. They also reported consistently more intense experiences under psilocybin than the small-standard deviants. The degree of variability on perceptual-behavioral measures, such as the SD on handwriting area, is significantly related to, and therefore a predictor of, the intensity of the ensuing drug-induced experience.

Author Affiliations
Baltimore

From the departments of psychiatry and pharmacology, the College of Medicine, Ohio State University, Columbus, and the Maryland Psychiatric Research Center, Baltimore.

Footnotes
Accepted for publication Nov 15, 1972.

Reprint requests to Maryland Psychiattric Research Center, Box 3235, Baltimore 21228 (Dr. Fisher).

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