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William T. McKinney, Jr., MD; Laurens D. Young, MD; Stephen J. Suomi; John M. Davis, MD

Arch Gen Psychiatry. 1973;29(4):490-494.

Abstract
Four rhesus monkeys which were subjected to partial social isolation during the first 11 months of life and which had consistently exhibited patterns of grossly abnormal behavior during the 1 years prior to the current study were treated with chlorpromazine.

Three of the four subjects showed significant decreases in their self-disturbance behaviors on 7.5 mg/day of chlorpromazine given as the liquid concentrate by nasogastric intubation. The fourth subject showed no change. Plasma chlorpromazine levels confirmed absorption of the drug in all subjects.

Author Affiliations
Madison, Wis; Nashville, Tenn

From the Department of Psychiatry and Primate Laboratory (Dr. McKinney), the Department of Psychiatry (Dr. Young), the University of Wisconsin School of Medicine, Madison; the Department of Psychology, the University of Wisconsin, Madison (S. Suomi); and the Department of Psychiatry and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tenn.

Footnotes
Accepted for publication March 8, 1973.

Read in part at the New Research Program of the American Psychiatric Association, Dallas, May 4, 1972.

Reprint requests to the University of Wisconsin Medical School, 1300 University Ave, Madison, WI 53706 (Dr. McKinney).

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ABSTRACT