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William R. Martin, MD; Virginia L. Sandquist

Arch Gen Psychiatry. 1974;30(1):31-33.

Abstract
A total of 175 mg of naltrexone monohydrate, suspended in small particles of a polylactide plastic (500 mg), was injected intramuscularly in dogs whose spinal cords had been transected at the T5-10 levels.

This produced a level of blockade against the effects of morphine (1 mg/kg) on the flexor and skin twitch reflex and pupillary diameter for a duration of 21 to 29 days. In some instances levels of blockade could still be detected 33 days after administration.

This preparation demonstrates the feasibility of a slow release form of a narcotic antagonist that may have value in the treatment of narcotic addicts.

Author Affiliations
Lexington, Ky

From the National Institute of Drug Abuse, Addiction Research Center, Lexington, Ky.

Footnotes
Accepted for publication Oct 9, 1973.

Reprint requests to NIDA Addiction Research Center, PO Box 2000, Lexington, KY 40507 (Dr. Martin).

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