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Contribution to a Permissive Hypothesis of Affective Disorders

Arthur J. Prange, Jr., MD; Ian C. Wilson, MD; Clabe W. Lynn, MD; Lacoe B. Alltop, MSPH; Rachel A. Stikeleather

Arch Gen Psychiatry. 1974;30(1):56-62.

Abstract
Five manic patients were treated with chlorpromazine hydrochloride (CPZ), then with L-tryptophan (LTP), and five with LTP first, then CPZ, in a double-blind, placebo-controlled crossover study. LTP was slightly superior to CPZ in all regards. Mania and depression may be linked by a central indoleamine deficit.

Author Affiliations
RN, Raleigh, NC

From the Department of Psychiatry, School of Medicine, and the Biological Sciences Research Center, University of North Carolina, Chapel Hill (Dr. Prange), and the Division of Research, North Carolina Mental Health Department, Dorothea Dix Hospital, Raleigh (Drs. Wilson and Lynn, Mr. Alltop, and Ms. Stikeleather).

Footnotes
Accepted for publication Sept 4, 1973.

Reprint requests to Department of Psychiatry, School of Medicine, University of North Carolina, Chapel Hill, NC 27514 (Dr. Prange).

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