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Lithium Carbonate and Sleep in Affective DisordersFurther Considerations
David J. Kupfer, MD;
Charles F. Reynolds III, MD;
Brian L. Weiss, MD;
F. Gordon Foster
Arch Gen Psychiatry. 1974;30(1):79-84.
Abstract
The effect of lithium carbonate on electroencephalographic sleep parameters was evaluated in six patients with affective disorders. Confirming earlier results, we report significant reductions in rapideye-movement (REM) percent and phasic-REM activity during the drug period. Doubling of delta-sleep time occurred during lithium administration, and a negative correlation between REM percent and delta percent was found; there was no immediate REM compensation in the postdrug period. We propose a model for REM suppression based on REM-cycle length and the presence or absence of REM rebound.
Author Affiliations
New Haven, Conn
From the Department of Psychiatry-Research, University of Pittsburgh School of Medicine. Dr. Foster is currently with Baylor University, Behavior Science Division, Academy of Health Science, Waco, Tex, and Dr. Reynolds is now at McGill University School of Medicine, Montreal.
Footnotes
Accepted for publication May 30, 1973.
Reprint requests to the Department of Psychiatry-Research, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O'Hara St, Pittsburgh, PA 15261 (Dr. Kupfer).
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