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Seymour Rosenblatt, MD; Jacob D. Chanley, PhD

Arch Gen Psychiatry. 1974;30(4):456-460.

Abstract
The pharmacological action of imipramine hydrochloride was determined by a method involving the infusion of tritiated norepinephrine and measuring the tritiated metabolites in urine. The effects of similar dosages of imipramine on norepinephrine metabolism varied between subjects and were probably due to individual differences in drug metabolism.

A significant correlation was found between an index of the reuptake inhibition by imipramine on peripheral sympathetic nerve endings and the improvement in the clinical state of depressed patients.

Author Affiliations
New York

From the Department of Psychiatry (Dr. Rosenblatt) and the Department of Biochemistry (Dr. Chanley), the Mount Sinai School of Medicine of the City University of New York.

Footnotes
Accepted for publication Oct 17, 1973.

Reprint requests to the Mount Sinai School of Medicine, Basic Sciences Bldg, 10 E 102nd St, New York, NY 10029 (Dr. Rosenblatt).

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ABSTRACT