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A Double-Blind Trial

Earl D. Hearst, MD; C. Robert Cloninger, MD; Eugene L. Crews, MD; Remi J. Cadoret, MD

Arch Gen Psychiatry. 1974;30(4):463-466.

Abstract
Twenty-eight patients participated in a controlled double-blind study to determine the effectiveness of electrosleep as a treatment modality. To our knowledge this is the first study in the English literature in which the peripheral rhythmic electrical stimulation has been eliminated, thereby allowing the results of the current effect on the brain to be independently evaluated.

Both global ratings by patients and physicians on the fifth day of treatment and on two-week follow-up indicate that current effect is not associated with significant improvement, although patient global ratings on day 5 indicate a trend in this direction. Self-rating scales by patients indicate no significant improvement for anxiety, insomnia, or somatic complaints. Depressive self-rating scales do show a significant improvement on day 5 of treatment, but no carry over effect to the two-week follow-up.

Author Affiliations
St. Louis

From the Department of Psychiatry, Washington University School of Medicine, St. Louis.

Footnotes
Accepted for publication Nov 26, 1973.

Reprint requests to the Psychiatric Associates of Tidewater, Medical Tower Bldg, Rm 402, Norfolk, VA 23507 (Dr. Hearst).

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