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George E. Murphy, MD; Robert A. Woodruff, Jr., MD; Marijan Herjanic, MD; Greg Super, MD

Arch Gen Psychiatry. 1974;30(6):757-761.

Abstract
In a five-year prospective follow-up study, 37 patients were concordant for the diagnosis of primary affective disorder at index and blind follow-up interview. This report describes their clinical course graphically.

Six patients (16%) were chronically ill during the entire follow-up period. Nine (24%) had no recurrence of depression. The remaining 22 patients had one to nine further depressive episodes with durations varying from two weeks to one year.

At follow-up, 13 patients were ill: six chronically plus seven others. Three fourths of the patients were well more than three fourths of the time during the follow-up interval, with few or no lingering symptoms.

Author Affiliations
St. Louis

From the Department of Psychiatry, Washington University School of Medicine, St. Louis.

Footnotes
Accepted for publication Jan 16, 1973.

Reprint requests to Renard Hospital, 4940 Audubon Ave, St. Louis, MO 63110 (Dr. Murphy).

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