This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Malcolm B. Bowers, Jr., MD

Arch Gen Psychiatry. 1974;31(1):50-54.

Abstract
Lumbar cerebrospinal fluid homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5HIAA), and probenecid were measured in groups of patients suffering from schizophrenia or affective disorder following administration of probenecid (100 mg/kg over 18 hours) to block acid monoamine metabolite egress from cerebrospinal fluid (CSF). The CSF HVA value was lower in the total schizophrenic group compared with that of the affective disorder group and in a poor prognosis group of schizophrenics compared with that in a good prognosis group. These differences could not be accounted for by differences in CSF probenecid. Comparable net increases in HVA were produced by antipsychotic drug administration in subgroups from the two groups of schizophrenics.

If clinical schizophrenia is characterized by increased central dopaminergic transmission, this increased transmission is not associated with increased central HVA formation, as determined by the measurement of lumbar CSF HVA following probenecid.

Author Affiliations
New Haven, Conn

From Yale University School of Medicine, 333 Cedar St. New Haven, Conn.

Footnotes
Accepted for publication March 28, 1974.

Reprint requests to Yale University, 333 Cedar St, New Haven, CT 06510 (Dr. Bowers).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Effects of Metabolic Perturbation on Plasma Homovanillic Acid in Schizophrenia: Relationship to Prefrontal Cortex Volume
Breier et al.
Arch Gen Psychiatry 1993;50:541-550.
ABSTRACT  

Cerebrospinal Fluid and Plasma Monoamine Metabolites and Their Relation to Psychosis: Implications for Regional Brain Dysfunction in Schizophrenia
Pickar et al.
Arch Gen Psychiatry 1990;47:641-648.
ABSTRACT  

Regional Cerebral Blood Flow and Cognitive Function in Huntington's Disease and Schizophrenia: A Comparison of Patients Matched for Performance on a Prefrontal-Type Task
Goldberg et al.
Arch Neurol 1990;47:418-422.
ABSTRACT  

Schneider's First-Rank Symptoms of Schizophrenia: An Association With Increased Growth Hormone Response to Apomorphine
Whalley et al.
Arch Gen Psychiatry 1984;41:1040-1043.
ABSTRACT  

Dopamine-beta-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy
van Kammen et al.
Science 1983;220:974-977.
ABSTRACT  

Aberrant Monoamine Metabolite Levels in CSF and Family History of Schizophrenia: Their Relationships in Schizophrenic Patients
Sedvall and Wode-Helgodt
Arch Gen Psychiatry 1980;37:1113-1116.
ABSTRACT  

Dopamine Excretion and Vulnerability to Drug-Induced Parkinsonism: Schizophrenic Patients
Crowley et al.
Arch Gen Psychiatry 1978;35:97-104.
ABSTRACT  

Dopamine and Serotonin Metabolism in Neuropsychiatrically Disturbed Children: CSF Homovanillic Acid and 5-Hydroxyindoleacetic Acid
Cohen et al.
Arch Gen Psychiatry 1977;34:545-550.
ABSTRACT  

Time-dependent effects of phenothiazines on dopamine turnover in psychiatric patients
Post and Goodwin
Science 1975;190:488-489.
ABSTRACT  

Cerebrospinal Fluid Amine Metabolites in Acute Schizophrenia
Post et al.
Arch Gen Psychiatry 1975;32:1063-1069.
ABSTRACT