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Jonathan Kaplan, MD; Susan Dawson; Thomas Vaughan, MD; Richard Green, MA; Richard Jed Wyatt, MD

Arch Gen Psychiatry. 1974;31(1):62-66.

Abstract
The sleep of 13 chronic male schizophrenics was studied during a one-month trial of chlorpromazine and compared with one-month placebo periods. Electroencephalographic recordings were made only after the patients had been on chlorpromazine hydrochloride or a placebo for at least three weeks.

Sleep latency and awake time were significantly decreased on chlorpromazine while stage II, delta sleep, delta%, nonrapid eye movement (NREM) sleep, REM activity, REM latency, and REM density were significantly increased. There were no significant changes in REM time, REM%, stage II%, and NREM%.

Author Affiliations
Washington, DC

From the Laboratory of Clinical Psychopharmacology, IRP, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, DC.

Footnotes
Accepted for publication Feb 28, 1974.

Reprint requests to the Laboratory of Clinical Psychopharmacology, National Institute of Mental Health, Division of Special Mental Health Research, IRP, Saint Elizabeths Hospital, WAW Bldg, Washington, DC 20032 (Dr. Kaplan).

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