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Theodore Van Putten, MD

Arch Gen Psychiatry. 1974;31(1):67-72.

Abstract
Patients with schizophrenia often do not take their prescribed phenothiazines. This survey focused on the drug-taking behavior of 85 mostly chronic schizophrenic patients during a two-year period.

Thirty-nine (46%) of these patients took less antipsychotic drug than the amount prescribed. The reluctance to take antipsychotic medication was significantly associated with extrapyramidal symptoms—most notably a subtle akathisia.

It is proposed that drug reluctance and dysphoric response to antipsychotic drugs are often extrapyramidally based.

Author Affiliations
Los Angeles

From the Brentwood VA Hospital and the UCLA School of Medicine, Los Angeles.

Footnotes
Accepted for publication Feb 17, 1974.

Reprint requests to the Brentwood VA Hospital, Wilshire and Sawtelle boulevards, Los Angeles, CA 90073 (Dr. Van Putten).

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