This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

John E. Helzer, MD; George Winokur, MD

Arch Gen Psychiatry. 1974;31(1):73-77.

Abstract
Thirty male manic probands and their first-degree relatives were investigated by means of a systematic psychiatric interview in order to determine the frequency of familial illness and possible mode of transmission of bipolar manic-depressive disorder. The infrequency of male-to-male transmission of affective disorder and the relative preponderance of the illness on the maternal side of the family both support similar previous findings that are suggestive of sex linkage in this illness. The incidence of alcoholism was found to be high and more prevalent on the paternal side of the families.

Author Affiliations
St. Louis

From the Department of Psychiatry, Washington University School of Medicine, St. Louis. Dr. Winokur is now with the Department of Psychiatry, University of Iowa College of Medicine, Iowa City.

Footnotes
Accepted for publication April 15, 1974.

Reprint requests to the Department of Psychiatry, Washington University, Barnes and Renard Hospitals, 4940 Audubon Ave, St. Louis, MO 63110 (Dr. Helzer).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Genetics of bipolar disorder
Craddock and Jones
J. Med. Genet. 1999;36:585-594.
ABSTRACT | FULL TEXT  

Mood-Lowering Effect of Tryptophan Depletion: Enhanced Susceptibility in Young Men at Genetic Risk for Major Affective Disorders
Benkelfat et al.
Arch Gen Psychiatry 1994;51:687-697.
ABSTRACT  

A Controlled Family History Study of Prepubertal Major Depressive Disorder
Puig-Antich et al.
Arch Gen Psychiatry 1989;46:406-418.
ABSTRACT  

Family History of Alcoholism in Borderline Personality Disorder
Loranger and Tulis
Arch Gen Psychiatry 1985;42:153-157.
ABSTRACT  

A Family Study of Schizoaffective, Bipolar I, Bipolar II, Unipolar, and Normal Control Probands
Gershon et al.
Arch Gen Psychiatry 1982;39:1157-1167.
ABSTRACT  

An Evaluation of the Family History Method for Ascertaining Psychiatric Disorders
Thompson et al.
Arch Gen Psychiatry 1982;39:53-58.
ABSTRACT  

Analysis of Familial Factors in Bipolar Affective Illness
Johnson and Leeman
Arch Gen Psychiatry 1977;34:1074-1083.
ABSTRACT  

Reduced MAO Activity in First-Degree Relatives of Individuals With Bipolar Affective Disorders: A Preliminary Report
Leckman et al.
Arch Gen Psychiatry 1977;34:601-606.
ABSTRACT  

Sex Differences and the Epidemiology of Depression
Weissman and Klerman
Arch Gen Psychiatry 1977;34:98-111.
ABSTRACT  

Etiological Factors in Manic-Depressive Psychoses
Hays
Arch Gen Psychiatry 1976;33:1187-1188.
ABSTRACT  

Psychiatric Illness in Fathers of Men With Bipolar Primary Affective Disorder
Dunner and Fieve
Arch Gen Psychiatry 1975;32:1134-1137.
ABSTRACT  

Bipolar Affective Disorder in Black and White Men: A Comparison of Symptoms and Familial Illness
Helzer
Arch Gen Psychiatry 1975;32:1140-1143.
ABSTRACT