 |
|
Long-Term Use of Marihuana and the Development of Tolerance or Sensitivity to 9Tetrahydrocannabinol
Mario Perez-Reyes, MD;
Martha C. Timmons;
Monroe E. Wall, PhD
Arch Gen Psychiatry. 1974;31(1):89-91.
Abstract
A group of 15 subjects who have used marihuana infrequently and a group of 15 subjects who have used the drug frequently were intravenously infused with  9-tetrahydrocannabinol.
In spite of the marked differences in marihuana use, the groups did not differ significantly in the amount of 9-THC necessary for its effects to be perceived, to accelerate the heart 25% above the base line levels, the total dose administered, the maximum level of "high," the maximum heart rate acceleration, and the heart rate acceleration observed 15 minutes after the beginning of the infusion.
This is evidence that marihuana, as currently used by young Americans does not produce tolerance or sensitivity to its effects.
Author Affiliations
Chapel Hill, NC; Research Triangle Park, NC
From the Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC (Drs. Perez-Reyes and Timmons), and the Research Triangle Park Institute, Research Triangle Park, NC (Dr. Wall).
Footnotes
Accepted for publication Jan 16, 1974.
Reprint requests to the University of North Carolina School of Medicine, Chapel Hill, NC 27514 (Dr. Perez-Reyes).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Marijuana Consumption and Tolerance to Physiological and Subjective Effects
Babor et al.
Arch Gen Psychiatry 1975;32:1548-1552.
ABSTRACT
Morphine-dependent rats: blockade of precipitated abstinence by tetrahydrocannabinol
Hine et al.
Science 1975;187:443-445.
ABSTRACT
|
