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Philip S. Holzman, PhD; Leonard R. Proctor, MD; Deborah L. Levy; Nicholas J. Yasillo; Herbert Y. Meltzer, MD; Stephen W. Hurt

Arch Gen Psychiatry. 1974;31(2):143-151.

Abstract
A simple test of smooth-pursuit eye movements disclosed a striking association between deviant eye tracking and clinically diagnosed schizophrenia. A high proportion of the schizophrenic patients' first-degree relatives who were not themselves clinically schizophrenic also showed deviant eye-tracking behavior. The relationship of poor eye tracking and schizophrenia is even stronger when specific psychological test evidence of thought disorder is used operationally to classify patients. The eye-tracking dysfunction may thus represent a genetic marker that can prove highly useful for studying the transmission of a vulnerability to schizophrenia. The findings suggest proprioceptive and interoceptive involvement in schizophrenic pathology.

Author Affiliations
From the departments of psychiatry (Drs. Holzman and Meltzer); surgery, Section of Otolaryngology (Dr. Proctor); and psychology (Ms. Levy and Mr. Hurt); and the Franklin McLean Memorial Research Institute (Mr. Yasillo), University of Chicago.

Footnotes
Accepted for publication May 14, 1974.

Reprint requests to the Department of Psychiatry, University of Chicago, 950 E 59th St, Chicago, IL 60637 (Dr. Holzman).

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