This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (49)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Report From the Boston Collaborative Drug Surveillance Program

Chester Swett, Jr., MD

Arch Gen Psychiatry. 1974;31(2):211-213.

Abstract
The frequency of drowsiness attributed to orally administered chlorpromazine hydrochloride was compared among 130 nonsmokers and 201 "light" and 72 "heavy" cigarette smokers. Drowsiness occurred in 16%, 11%, and 3%, respectively. More rapid metabolism of chlorpromazine in cigarette smokers may explain these findings.

Author Affiliations
From the Boston Collaborative Drug Surveillance Program (BCDSP), Boston University Medical Center.

Footnotes
Accepted for publication Feb 28, 1974.

Reprint requests to Boston Collaborative Drug Surveillance Program, 400 Totten Pond Rd, Waltham, MA 02154 (Dr. Swett).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Effects of smoking on the pharmacokinetics of erlotinib.
Hamilton et al.
Clin. Cancer Res. 2006;12:2166-2171.
ABSTRACT | FULL TEXT  

Hypotension Due to Chlorpromazine: Relation to Cigarette Smoking, Blood Pressure, and Dosage
Swett et al.
Arch Gen Psychiatry 1977;34:661-663.
ABSTRACT