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Protirelin (TRH) in Depression
Leo E. Hollister, MD;
Philip Berger, MD;
Floradell L. Ogle, RN;
Roger C. Arnold, MD;
August Johnson, PhD
Arch Gen Psychiatry. 1974;31(4):468-470.
Abstract
Protirelin (formally known as thyrotrophin releasing hormone [TRH]) was evaluated as a treatment in depression in two independent investigations using a similar protocol. The latter was designed so that some patients received three 600µg intravenous injections of protirelin early in their course and others received them toward the end of their course of treatment. Regardless of when protirelin was given in the course of depression, or how the course of the illness was measured, it seemed to be devoid both of therapeutic and of major adverse effects.
Author Affiliations
From the Veterans Administration Hospital, Palo Alto, Calif (Drs. Hollister and Berger and Ms. Ogle); and the Veterans Administration Hospital, Danville, Ill (Drs. Arnold and Johnson).
Footnotes
Accepted for publication June 10, 1974.
Reprint requests to 3801 Miranda Ave, Palo Alto, CA 94304 (Dr. Hollister).
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