This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Michael A. Schwartz, MD; Richard J. Wyatt, MD; Hsiu-Ying T. Yang, PhD; Norton H. Neff, PhD

Arch Gen Psychiatry. 1974;31(4):557-560.

Abstract
Two forms of monoamine oxidase were identified in 15 regions of the brain. These enzymes were ientified by their sensitivity to the drugs clorgyline and N-(1-phenylisopropyl)-N-methyl-N-propionylamine (E 250 or Deprenyl, Hungary) and by their ability to deaminate serotonin and β-phenylethylamine. Enzyme activity was rather uniformly distributed in the brain. There were no statistically significant differences of enzyme activity when compared in three regions of the brain from mentally normal and chronic schizophrenic subjects. There were, however, large variations of enzyme activities within the groups of subjects tested that could have masked true differences of enzyme activity.

Author Affiliations
From the Laboratory of Clinical Psychopharmacology (Drs. Schwartz and Wyatt) and Laboratory of Preclinical Pharmacology (Drs. Yang and Neff), National Institute of Mental Health, St. Elizabeths Hospital, Washington, DC. Dr. Schwartz is now with the New York Hospital-Cornell Medical Center, Westchester Division, White Plains, NY.

Footnotes
Accepted for publication May 21, 1974.

Reprint requests to the Laboratory of Clinical Psychopharmacology, National Institute of Mental Health, St. Elizabeths Hospital, WAW Building, Washington, DC 20032 (Dr. Schwartz).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Human Monoamine Oxidase: Lack of Brain and Platelet Correlation
Young et al.
Arch Gen Psychiatry 1986;43:604-609.
ABSTRACT  

Brain Monoamine Oxidase Activity in Schizophrenics and Controls
Reveley et al.
Arch Gen Psychiatry 1981;38:663-665.
ABSTRACT  

Skeletal Muscle MAO Activity in the Major Psychoses: Relationship With Platelet and Plasma MAO Activities
Meltzer and Arora
Arch Gen Psychiatry 1980;37:333-339.
ABSTRACT  

Decreased Platelet Monoamine Oxidase Activity in Chronic Schizophrenia, Shown With Novel Substrates
Berrettini et al.
Arch Gen Psychiatry 1978;35:600-605.
ABSTRACT  

Possible Changes in Striatal and Limbic Cholinergic Systems in Schizophrenia
McGeer and McGeer
Arch Gen Psychiatry 1977;34:1319-1323.
ABSTRACT  

The Human Platelet: A Diagnostic and Research Tool for the Study of Biogenic Amines in Psychiatric and Neurologic Disorders
Stahl
Arch Gen Psychiatry 1977;34:509-516.
ABSTRACT  

Platelet Monamine Oxidase in Schizophrenia: An Investigation in Drug-Free Chronic Hospitalized Patients
Owen et al.
Arch Gen Psychiatry 1976;33:1370-1373.
ABSTRACT