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Leon Cytryn, MD; Donald H. McKnew, Jr., MD; Ramesh B. Desai, PhD

Arch Gen Psychiatry. 1974;31(5):659-661.

Abstract
In a preliminary study, nine children aged 6 to 12 years, with affective disorders, were studied during a two- to three-week hospitalization. Biochemical as well as behavioral data were collected. The urinary metabolites studied were norepinephrine, vanillymandelic acid, and 3-methoxy-4-hydroxyphenylethyl glycol. Deviations from values in normal controls were found in all the children, but were most apparent in those with chronic affective disorders. This suggests that clinical investigation of the biology of such childhood disorders may be relevant for issues of cause or treatment as they have been in adult affective disorders.

Author Affiliations
Mayada Logue

From the departments of psychiatry, Children's Hospital of the District of Columbia (Drs. Cytryn, McKnew, Desai, and Ms Logue) and the George Washington University School of Medicine, Washington, DC (Drs. Cytryn and McKnew).

Footnotes
Accepted for publication June 19, 1974.

Reprint requests to the Department of Psychiatry, Children's Hospital of the District of Columbia, 2125 13th St NW, Washington, DC 20009 (Dr. Cytryn).

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