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A Further Family Study of Manic-Depressive Illness

Ugo Goetzl, MD; Ronald Green, MD; Peter Whybrow, MD, DPM; Rebecca Jackson, MD

Arch Gen Psychiatry. 1974;31(5):665-672.

Abstract
We performed a family study of 39 individuals with proven manic-depressive disorder. Among the affected first-degree relatives of these probands, an overall parity of the male-female ratio was found. In addition, there were four instances of father-son transmission of affective illness involving probands of the sample.

These results suggest that any gene locus that exists on the X chromosome is not of itself a sufficient or necessary condition for the transmission of manic-depressive illness. Hence, any implication that X linkage is the primary mode of transmission in manic-depressive illness is premature.

Author Affiliations
From the Department of Psychiatry, Dartmouth Medical School, Hanover, NH. Dr. Goetzl is now with the Department of Psychiatry, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey.

Footnotes
Accepted for publication July 8, 1974.

Reprint requests to the Department of Psychiatry, Dartmouth Medical School, Hanover, NH 03755 (Dr. Whybrow).

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