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Thomas J. Crowley, MD; A. J. Stynes, MS; Marilyn Hydinger; I. Charles Kaufman, MD

Arch Gen Psychiatry. 1974;31(6):829-838.

Abstract
We find significant dose-response curves for social behaviors after single-dose administration of drugs in five adult male monkeys living in their "home" troop of about 30 animals. Ethanol (0 to 2 ml/kg, gavage) produced ataxia without motor slowing, regressive playful fighting typical of juveniles, and a substantial increase in the ratio of heterosexual to autosexual behaviors. Aggressive dominance behavior was not altered. Pentobarbital sodium (0 to 1 mg/kg, intramuscularly) reduced submission behaviors, increasing the dominance-to-submission ratio. Methamphetamine hydrochloride (0 to 0.5 mg/kg intramuscularly) decreased the dominance-to-submission ratio, while producing hyperactivity, stereotypies, and social unrelatedness. Morphine (0 to 0.4 mg/kg, intramuscularly) blocked sexual behavior without impairing motor activity.

The results may help to clarify some controversies arising from conflicting data in studies of drug effects on humans.

Author Affiliations
From the Primate Biobehavioral Laboratory, Department of Psychiatry, University of Colorado Medical Center, Denver.

Footnotes
Accepted for publication Aug 5, 1974.

Read in part before the annual meeting of the American Psychiatric Association, Detroit, Mich, May 6, 1974.

Reprint requests to the Department of Psychiatry, University of Colorado Medical Center, 4200 E Ninth Ave, Denver, CO 80220 (Dr. Crowley).

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