Amine Precursors and Depression

doi:10.1001/archpsyc.1975.01760190024002

You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.

Vol. 32 No. 1, January 1975

Online Only
	•	Online First Table of Contents

ORIGINAL ARTICLES

•	Online Features

This Article
•	References
•	Full text PDF
•	Reply to article
•	Send to a friend
•	Save in My Folder
•	Save to citation manager
•	Permissions

Citing Articles
•	Citation map
•	Citing articles on HighWire
•	Citing articles on Web of Science (86)
•	Contact me when this article is cited

Related Content
•	Similar articles in this journal

Social Bookmarking
	What's this?

Amine Precursors and Depression

Joe Mendels, MD; James L. Stinnett, MD; David Burns, MD; Alan Frazer, PhD

Arch Gen Psychiatry. 1975;32(1):22-30.

Abstract

The amino acid precursors, levodopa and L-tryptophan, were givento a group of hospitalized depressed patients in a double-blindplacebo controlled study. Relatively large doses were not associatedwith sufficient clinical improvement to allow the patients toleave the hospital.

Previous studies using the precursor-load strategy have producedconflicting findings on the use of these compounds for depressedpatients.

Author Affiliations

From the Depression Research Unit, departments of psychiatry (Drs. Mendels, Stinnett, Burns, and Frazer) and pharmacology (Dr. Frazer), University of Pennsylvania and the Veterans Administration Hospital, Philadelphia.

Footnotes

Accepted for publication Sept 24, 1974.

Reprint requests to the Veterans Administration Hospital, Universityand Woodland Aves, Philadelphia, PA 19104 (Dr. Mendels).

Add to CiteULike CiteULike Add to Connotea Connotea Add to Delicious Delicious Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

L-Tryptophan: A Rational Anti-Depressant and a Natural Hypnotic?
Boman
Aust N Z J Psychiatry 1988;22:83-97.
ABSTRACT

Tyrosine for the Treatment of Depression
Gelenberg and Gibson
Nutrition and Health 1984;3:163-173.
ABSTRACT

Effect of 5-Hydroxytryptophan on Serum Cortisol Levels in Major Affective Disorders: I. Enhanced Response in Depression and Mania
Meltzer et al.
Arch Gen Psychiatry 1984;41:366-374.
ABSTRACT

Improvement of Depression by REM Sleep Deprivation: New Findings and a Theory
Vogel et al.
Arch Gen Psychiatry 1980;37:247-253.
ABSTRACT

Effects of a Dopamine Agonist Piribedil in Depressed Patients: Relationship of Pretreatment Homovanillic Acid to Antidepressant Response
Post et al.
Arch Gen Psychiatry 1978;35:609-615.
ABSTRACT

Clinical and Biochemical Heterogeneity of Depressive Disorders
MAAS
ANN INTERN MED 1978;88:556-563.
ABSTRACT

CNS Monoamine Metabolism in Bipolar Affective Disorder: Evaluation Using a Peripheral Decarboxylase Inhibitor
Garfinkel et al.
Arch Gen Psychiatry 1977;34:735-739.
ABSTRACT

Total and Free Plasma Tryptophan Levels in Patients With Affective Disorders: Effects of a Peripheral Decarboxylase Inhibitor
Garfinkel et al.
Arch Gen Psychiatry 1976;33:1462-1466.
ABSTRACT

Biogenic Amines and Depression: Biochemical and Pharmacological Separation of Two Types of Depression
Maas and Maas
Arch Gen Psychiatry 1975;32:1357-1361.
ABSTRACT

The Basis for Amine Hypotheses in Affective Disorders: A Critical Evaluation
Baldessarini
Arch Gen Psychiatry 1975;32:1087-1093.
ABSTRACT

| | |