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Frederic Quitkin, MD; Arthur Rifkin, MD; Donald F. Klein, MD

Frederic Quitkin, MD; Arthur Rifkin, MD; Donald F. Klein, MD

Arch Gen Psychiatry. 1975;32(10):1276-1281.

Abstract
• Previous work with chronic schizophrenic patients and a pilot study with nonchronic treatment-refractory schizophrenic patients indicated that very high doses of fluphenazine hydrochloride (1,200 mg/day) have a greater antipsychotic effect than do standard doses. Increased side-effects were not reported. In a double-blind six-week random assignment study, 18 nonchronic treatment-refractory patients received the very high dose and 13 the standard dose.

The standard-dose treated patients had greater improvement on a variety of measures. Analysis of Inpatient Multidimensional Psychiatric Scale scores indicated that some patients taking very high doses had akinesia, an extrapyramidal side-effect that in part accounted for their inferior response.

Author Affiliations
From the Long Island Jewish-Hillside Medical Center, Hillside Division, Glen Oaks, NY.

Footnotes
Accepted for publication Dec 18, 1974

Reprint requests to the Long Island Jewish-Hillside Medical Center, Hillside Division, PO Box 38, Glen Oaks, NY 11004 (Dr Quitkin).

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