This Article  • References  • Full text PDF  • Correction  • Correction  • Correction  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (45)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Ellen R. Gritz, PhD; Saul M. Shiffman, MA; Murray E. Jarvik, MD, PhD; Jochen Haber, MS; Anthony M. Dymond, PhD; Roger Coger, PhD; V. Charuvastra, MD; Joseph Schlesinger, MD

Arch Gen Psychiatry. 1975;32(2):237-242.

Abstract
Methadone hydrochloride-maintenance outpatients were compared to abstinent exaddicts on physiological and psychological measures, and to normal subjects on physiological measures. The battery of psychological tests measure cognitive abilities and mental state. Methadone depressed respiration rate below other groups; abstinent subjects had higher heart rates than methadone or control subjects. No other physiological differences appeared.

Electroencephalographic spectral analysis disclosed that the location of the alpha peak was at the lowest frequency in the methadone group, next lowest being the abstinent group. Discriminant functions based on a weighted combination of variables (frequencies) successfully distinguished the EEGs of the three groups. Both discriminant analysis and multiple regression analysis indicated that EEG changes were dose-dependent. Methadone subjects performed significantly poorer on several tests of learning and immediate recall compared to abstinent subjects.

Author Affiliations
From the Veterans Administration Hospital Brentwood, Los Angeles (Drs. Gritz, Jarvik, Dymond, Coger, Charuvastra, and Schlesinger); and the departments of psychiatry (Drs. Gritz, Jarvik, Coger, Schlesinger, and Charuvastra and Mr. Shiffman) and psychology (Mr. Shiffman), the Brain Research Institute (Dr. Dymond), and the Health Science Computing Facility (Mr. Haber), University of California, Los Angeles.

Footnotes
Accepted for publication Sept 26, 1974.

Reprint requests to the Veterans Administration Hospital Brentwood, 530/T2, Los Angeles, CA 90073, CA (Dr. Gritz).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Reorganization of the composition of brain oscillations and their temporal characteristics during opioid withdrawal
Fingelkurts et al.
J Psychopharmacol 2008;22:270-284.
ABSTRACT  

Diagnosis and Symptoms of Depression in Opiate Addicts: Course and Relationship to Treatment Outcome
Rounsaville et al.
Arch Gen Psychiatry 1982;39:151-156.
ABSTRACT  

Failure of Methadone and Levomethadyl Acetate (Levo-Alpha-Acetylmethadol, LAAM) Maintenance to Affect Memory
Grevert et al.
Arch Gen Psychiatry 1977;34:849-853.
ABSTRACT  

Symptom Patterns in Primary and Secondary Depression: A Comparison of Primary Depressives With Depressed Opiate Addicts, Alcoholics, and Schizophrenics
Weissman et al.
Arch Gen Psychiatry 1977;34:854-862.
ABSTRACT