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II. An in Vivo Study of Lithium Ion Distribution Across Erythrocyte Membranes

Arthur P. Schless, MD; Alan Frazer, PhD; Joe Mendels, MD; Ghanshyam N. Pandey, PhD; Vassilios J. Theodorides, PhD

Arch Gen Psychiatry. 1975;32(3):337-340.

Abstract
A study was conducted to determine if membrane factors, known to influence the distribution of sodium ion (Na) and potassium ion (K), also influence lithium ion distribution. Two groups of sheep with genetically determined differences in their cation concentrations were administered lithium chloride for ten days. The low red blood cell (RBC) potassium ion sheep (LK) had a greater RBC lithium ion concentration than the high RBC potassium ion sheep (HK).

In vitro incubation of erythrocytes with lithium chloride also produced substantially different RBC lithium ion: plasma lithium ion ratios similar to those seen in the in vivo study. Distribution of lithium ion was generally similar to that of Na ion. It seems that lithium ion distribution may be controlled by the same genetic factors that regulate Na ion distribution.

Author Affiliations
From the Depression Research Unit, Veterans Administration Hospital (Drs. Schless, Frazer, Mendels, and Pandey); the departments of psychiatry (Drs. Schless, Frazer, Mendels, and Pandey), and pharmacology (Dr. Frazer), University of Pennsylvania School of Medicine; and Smith Kline Laboratories (Dr. Theodorides), Philadelphia.

Footnotes
Accepted for publication July 18, 1974.

Read in part before the annual meeting of the Federation of American Societies for Experimental Biology, Atlantic City, NJ, April 16, 1973.

Reprint requests to the Veterans Administration Hospital (151E), University and Woodland Ave, Philadelphia, PA 19104 (Dr. Mendels).

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