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David Wheatley, MD

Arch Gen Psychiatry. 1975;32(5):653-655.

Abstract
It has been suggested that depression is a disease of cholinergic dominance and since the beta-adrenergic blocking drug propranolol hydrochloride can cause depression, there arises the possibility that a beta-adrenergic stimulant could benefit the condition.

For ethical reasons, the adrenergic drug metaproterenol sulfate was combined with chlordiazepoxide hydrochloride and compared to placebo and chlordiazepoxide in a formal double-blind trial. However, the results did not show any advantage for the addition of metaproterenol either in respect of enhanced antidepressant effect or a reduced incidence, nature, or severity of side-effects.

Author Affiliations
From the General Practitioner Research Group, Twickenham, England.

Footnotes
Accepted for publication Sept 26, 1974.

Reprint requests to the General Practitioner Research Group, 325 Staines Rd, Twickenham, TW2 5Ax, England (Dr. Wheatley).

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