A Review of REM Sleep Deprivation

doi:10.1001/archpsyc.1975.01760240077006

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Vol. 32 No. 6, June 1975

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A Review of REM Sleep Deprivation

Gerald W. Vogel, MD

Arch Gen Psychiatry. 1975;32(6):749-761.

Abstract

Studies on the behavioral consequences of rapid eye movement(REM) sleep deprivation in animals and humans are criticallyreviewed. In animals, converging evidence—some reasonablywell controlled—indicates that REM sleep deprivation probablyheightens central neural excitability and increases motivationalbehavior, but has unclear or inconclusive effects on learning.In humans, evidence indicates that REM sleep deprivation isnot dream deprivation and is not harmful to schizophrenic, depressed,or healthy subjects. Controversy continues about whether ornot (some) schizophrenic patients respond abnormally to REMsleep deprivation by having no REM rebound. Controlled but unconfirmedwork indicates that endogenous, but not reactive, depressivepatients are improved by REM sleep deprivation, a finding consistentwith the animal behavioral consequences of the procedure andwith the unique REM-depriving properties of efficacious antidepressantdrugs.

Author Affiliations

From the Georgia Mental Health Institute and the Department of Psychiatry, Emory University, Atlanta.

Footnotes

Accepted for publication Feb 21, 1975.

Read in part before the Association for the PsychophysiologicalStudy of Sleep, Jackson Hole, Wyo, June 6, 1974.

Reprint requests to the Sleep Lab, Georgia Mental Health Institute,1256 Briarcliff Rd NE, Atlanta, GA 30306 (Dr. Vogel).

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