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Gerald W. Vogel, MD

Arch Gen Psychiatry. 1975;32(6):749-761.

Abstract
Studies on the behavioral consequences of rapid eye movement (REM) sleep deprivation in animals and humans are critically reviewed. In animals, converging evidence—some reasonably well controlled—indicates that REM sleep deprivation probably heightens central neural excitability and increases motivational behavior, but has unclear or inconclusive effects on learning. In humans, evidence indicates that REM sleep deprivation is not dream deprivation and is not harmful to schizophrenic, depressed, or healthy subjects. Controversy continues about whether or not (some) schizophrenic patients respond abnormally to REM sleep deprivation by having no REM rebound. Controlled but unconfirmed work indicates that endogenous, but not reactive, depressive patients are improved by REM sleep deprivation, a finding consistent with the animal behavioral consequences of the procedure and with the unique REM-depriving properties of efficacious antidepressant drugs.

Author Affiliations
From the Georgia Mental Health Institute and the Department of Psychiatry, Emory University, Atlanta.

Footnotes
Accepted for publication Feb 21, 1975.

Read in part before the Association for the Psychophysiological Study of Sleep, Jackson Hole, Wyo, June 6, 1974.

Reprint requests to the Sleep Lab, Georgia Mental Health Institute, 1256 Briarcliff Rd NE, Atlanta, GA 30306 (Dr. Vogel).

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