This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (24)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Edward J. Sachar, MD; Peter H. Gruen, MD; Toksoz B. Karasu, MD; Norman Altman, MD; Andrew G. Frantz, MD

Arch Gen Psychiatry. 1975;32(7):885-886.

Abstract
Thioridazine, unlike most other effective antipsychotic drugs, appears to be only a weak dopamine antagonist in various regions of the brain. We decided to test, indirectly, thioridazine's effects on another brain dopaminergic system, the tuberoinfundibular tract, which regulates prolactin secretion by stimulating hypothalamic secretion of prolactin-inhibiting factor. Chlorpromazine and several other phenothiazines have been shown to stimulate prolactin secretion.

Five healthy men ingested 50 mg of chlorpromazine concentrate on one occasion, and 50 mg of thioridazine concentrate on another. Both drugs noticeably stimulated prolactin secretion within two hours. It is concluded that thioridazine is a potent dopamine antagonist in the tuberoinfundibular system, and it is suggested that this system's regulation of prolactin secretion may provide a useful method for studying antipsychotic drug effects in man.

Author Affiliations
From the Department of Psychiatry, Albert Einstein College of Medicine, Bronx, NY (Drs. Sachar, Gruen, Karasu, and Altman); and the Department of Medicine, Columbia University College of Physicians and Surgeons, New York, (Dr. Frantz).

Footnotes
Accepted for publication Feb 21, 1975.

Reprint requests to the Department of Psychiatry, Bronx Municipal Hospital Center, Eastchester Road and Pelham Parkway S, Bronx, NY 10461 (Dr. Sachar).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Hyperprolactinemia and possibly related development of prolactinoma during amisulpride treatment; three cases
Akkaya et al.
J Psychopharmacol 2009;23:723-726.
ABSTRACT  

Effect of Risperidone on Prolactinoma Growth in a Psychotic Woman
Pal and Sarino
Psychosom. Med. 2000;62:736-738.
ABSTRACT | FULL TEXT  

Thiethylperazine: Clinical Antipsychotic Efficacy and Correlation With Potency in Predictive Systems
Rotrosen et al.
Arch Gen Psychiatry 1978;35:1112-1118.
ABSTRACT  

Prolactin Responses to Neuroleptics in Normal and Schizophrenic Subjects
Gruen et al.
Arch Gen Psychiatry 1978;35:108-116.
ABSTRACT  

The Effect of Neuroleptics on Serum Prolactin in Schizophrenic Patients
Meltzer and Fang
Arch Gen Psychiatry 1976;33:279-286.
ABSTRACT