This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Effect of Dosage Regimen on Steady State Blood Levels

Thomas B. Cooper, MA; George M. Simpson, MD; E. Janet Haher; Per-Erik E. Bergner, MSC, MD

Arch Gen Psychiatry. 1975;32(7):903-905.

Abstract
Experimental evidence showed that a higher whole blood steady state drug plasma level was achieved when a patient was given medication three times a day compared to the same total daily dose once a day. In addition, evidence indicated possible enzyme induction by butaperazine in one patient.

We have demonstrated that the general stochastic theory developed to investigate the pharmacokinetics of lithium carbonate "in vivo" has more general applicability in that it applies also to dutaperazine, and facilitates interpretation of findings (without blood level data) in one other drug study.

Author Affiliations
From the Research Center, Rockland State Hospital, Orangeburg, NY.

Footnotes
Accepted for publication Aug 28, 1974.

Reprint requests to Rockland State Hospital, Research Center, Orangeburg, NY 10962 (Mr. Cooper).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Blood Levels of Neuroleptic Drugs in Nonresponding Chronic Schizophrenic Patients
Smith et al.
Arch Gen Psychiatry 1979;36:579-584.
ABSTRACT