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A Study in Control Subjects and Schizophrenic Patients

Angelo Carenzi, MD; J. Christan Gillin, MD; Allesandro Guidotti, MD; Michael A. Schwartz, MD; Marco Trabucchi, MD; Richard J. Wyatt, MD

Arch Gen Psychiatry. 1975;32(8):1056-1059.

Abstract
Striatal adenylyl cyclase activity from autopsied human brain is selectively stimulated by low concentrations of dopamine. Under the experimental conditions used, norepinephrine was about three times less potent than dopamine. Histamine and serotonin were ineffective. The stimulation by dopamine was competitively inhibited by haloperidol. There was no difference between the basal adenylyl cyclase activity or its level after dopamine stimulation between nine control subjects without a psychiatric history and seven patients with chronic schizophrenia.

Author Affiliations
From the Laboratory of Preclinical Pharmacology (Drs. Carenzi, Guidotti, and Trabucchi), and the Laboratory of Clinical Psychopharmacology (Drs. Gillin and Wyatt), National Institute of Mental Health, St. Elizabeths Hospital, Washington, DC. Dr. Schwartz is now with the New York Hospital Cornell Medical Center, White Plains.

Footnotes
Accepted for publication April 21, 1975.

Reprint requests to the National Institute of Mental Health, St. Elizabeths Hospital, WAW Building, Washington, DC 20032 (Dr. Wyatt).

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