This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (94)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

An in Vitro and in Vivo Monozygotic-Dizygotic Twin Study

Elizabeth Dorus, PhD; Ghanshyam N. Pandey, PhD; John M. Davis, MD

Arch Gen Psychiatry. 1975;32(9):1097-1102.

Abstract
• In previous research, evidence was provided of genetic control of in vitro red blood cell (RBC) uptake of lithium ion following a 24-hour incubation using a monozygotic (MZ)-dizygotic (DZ) twin study method. To extend these data, in vitro RBC lithium ion concentrations were assessed for five MZ and five DZ twin pairs. To extend this line of research on genetic control of lithium ion distribution to in vivo conditions, these twin pairs were administered lithium carbonate for seven days during which time RBC and plasma lithium ion concentrations were assessed. In this limited sample, the data provide evidence of genetic control of distribution of lithium ion across the RBC membrane in vivo as well as of in vitro RBC uptake of lithium ion.

Author Affiliations
From the Research Department, Illinois State Psychiatric Institute (Drs. Dorus, Pandey, and Davis); and the Department of Psychiatry, University of Chicago (Drs. Pandey and Davis). Dr. Dorus is now with the Department of Medicine, University of Chicago.

Footnotes
Accepted for publication May 22, 1975.

Reprint requests to the Department of Medicine, University of Chicago, 950 E 59th St, Chicago, IL 60637 (Dr. Dorus).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Lithium Ratio In Vitro: Diagnosis and Lithium Carbonate Response in Psychotic Patients
Garver et al.
Arch Gen Psychiatry 1984;41:497-505.
ABSTRACT  

Lithium Ion Transport and Affective Disorders Within Families of Bipolar Patients: Identification of a Major Gene Locus
Dorus et al.
Arch Gen Psychiatry 1983;40:545-552.
ABSTRACT  

Lithium Transport Across the RBC Membrane: A Study of Genetic Factors
Dorus et al.
Arch Gen Psychiatry 1980;37:80-81.
ABSTRACT  

Lithium transport across red cell membrane: a cell membrane abnormality in manic-depressive illness
Dorus et al.
Science 1979;205:932-934.
ABSTRACT  

Lithium Transport in Human Red Blood Cells: Genetic and Clinical Aspects
Pandey et al.
Arch Gen Psychiatry 1979;36:902-908.
ABSTRACT  

The Erythrocyte Lithium-Plasma Lithium Ratio in Patients With Primary Affective Disorder
Ramsey et al.
Arch Gen Psychiatry 1979;36:457-461.
ABSTRACT