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Willem van den Burg; Rutger H. van den Hoofdakker, MD, PhD

Arch Gen Psychiatry. 1975;32(9):1121-1125.

Abstract
• Ten endogenous depressive patients were deprived of sleep for two whole nights according to the following schedule: sleep/sleep deprivation/sleep/sleep deprivation/sleep. No drugs were administered. Experimental conditions were as neutral as possible. Blind and nonblind ratings were taken.

The patients were generally rated as improved after sleep deprivation, but a substantial effect, though temporary with rapid relapse, occurred in only two cases. After subsequent sleep, relapse followed as a rule. The net antidepressive effect of the total procedure was slightly more than nil.

Author Affiliations
From the Department of Biological Psychiatry, Psychiatric University Clinic, State University, Groningen, Netherlands.

Footnotes
Accepted for publication Feb 24, 1975.

Reprint requests to the Department of Biological Psychiatry, University Hospital, Oostersingel 59, Groningen, Netherlands (Mr. van den Burg).

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