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Comparison With Schizophrenia and Affective Disorder by Sex, Age of Admission, Precipitant, Outcome, and Family History

Ming T. Tsuang, MD, PhD; G. Michael Dempsey, MD; Frederick Rauscher, MD

Arch Gen Psychiatry. 1976;33(10):1157-1160.

Abstract
• Eighty-five cases of atypical schizophrenia were compared with 200 of schizophrenia, 100 of bipolar (mania), and 225 of unipolar (depression) affective disorder. Comparisons were made on the basis of sex, age at admission, precipitating factors, outcome, and a family history of schizophrenia or of affective disorder. The atypical schizophrenia differed remarkably from the schizophrenia and most closely resembled the bipolar affective disorder when allowance was made for a younger age at onset and a higher frequency of precipitants. An analysis of symptoms verified the predominance of schizophrenic features in the atypical schizophrenia, but also showed a high percentage (80%) of patients who had one or more manic symptoms at index admission. It is concluded that great care should be taken in diagnosing schizophrenia in a patient who also has manic symptoms.

Author Affiliations
From the Department of Psychiatry, University of Iowa College of Medicine, Iowa City. Dr Dempsey is now with New York State Psychiatric Institute, New York, and Dr Rauscher is currently with the Division of Special Mental Research, St Elizabeth's Hospital, Washington, DC.

Footnotes
Accepted for publication Feb 11, 1976.

Reprint requests to Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA 52242 (Dr Tsuang).

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