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A Survey of the Literature

Warren R. Procci, MD

Arch Gen Psychiatry. 1976;33(10):1167-1178.

Abstract
• The classification of functional psychoses has traditionally been dichotomous with schizophrenia and manic-depressive disorder, which are considered separate entities. However, the psychiatric literature is replete with descriptions of psychoses with mixed features. A variety of names has been applied to these psychoses, including the term "schizo-affective." Confusion exists regarding the nature of these psychoses, much of it resulting from a tendency to limit investigation to an acute view of symptom complexes.

This article examines the schizo-affective states across a variety of dimensions, including the acute symptomatologic picture, response to lithium carbonate therapy, follow-up studies, family history, and genetics. While the term "schizoaffective," as commonly used, probably describes a heterogeneous group of psychoses, considerable evidence supports the hypothesis that at least a subgroup of these psychoses has a definite relationship to the major affective disorders.

Author Affiliations
From the Department of Psychiatry, University of Southern California School of Medicine, Los Angeles.

Footnotes
Accepted for publication Dec 19, 1975.

Reprint requests to 1237 N Mission Rd, Los Angeles, CA 90033 (Dr Procci).

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